2021 Mercedes-Benz S-Class Report

Known issues, recalls, running costs, and what to check before you buy.

Updated Jun 14, 2026Daniel Wilson
2021 Mercedes-Benz S-Class Report

Overall Score

Our Verdict
Proceed with caution

Key Takeaways

  • Exceptional initial reliability with no reported recalls or consumer complaints.
  • Offers a high level of luxury, comfort, and advanced technology for its class.
  • Potential for significant maintenance and repair costs due to complex systems.
  • Thorough inspection is crucial to identify any wear on complex electronic and mechanical components.
Overview

2021 Mercedes-Benz S-Class

The 2021 Mercedes-Benz S-Class represents the pinnacle of automotive luxury and engineering for its model year. As a used vehicle, it offers a compelling blend of advanced technology, supreme comfort, and potent performance. Its near-flawless record regarding recalls and consumer complaints at launch is a significant indicator of its robust build quality and initial reliability. Shoppers can expect a refined driving experience, though the complexity inherent in a flagship luxury sedan warrants thorough pre-purchase inspection.

Critical Failure Risk

Exceptional initial reliability with no reported recalls or consumer complaints.

Early detection can reduce the odds of major repair bills.

Open Maintenance Analysis →

Reliability

Practicality

The score is supported by solid day-to-day usability signals.

Buyer Fit

Who This Car Is For

Best for

Buyers seeking a used luxury sedan with a strong emphasis on comfort and advanced technology.

+2 more buyer-fit notes in the full report

Avoid if

Budget-conscious buyers concerned about long-term running costs.

+2 more buyer-fit warnings in the full report

2021 Mercedes-Benz S-Class Reliability Analysis

Explore comprehensive reliability data including official safety recalls, consumer complaints, and common mechanical failures for the 2021 Mercedes-Benz S-Class.

Limited reliability records are available for this model year.

Specs

Vehicle Specs

Seating Capacity
5
Horsepower
429-496 hp
Torque
384-516 lb-ft
Transmission
Automatic
Drivetrain
AWD
Body Style
Chassis Cab
MSRP Range
$109,800 - $132,450

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Most Common Issues

No complaint hotspot data available yet.

See all common issues in the maintenance guide

First Service Interval

- Synthetic Oil Change (5W-40) (Parts: 5W-40 Synthetic Oil, Oil Filter) - Tire Rotation and Pressure Check - Brake System Inspection - Fluid Level Checks (Coolant, Brake, Washer)

Est. shop cost: $250 - $400

10,000 mi

Unlock the full maintenance guide for every scheduled service interval and cost forecast.

Full pre-purchase inspection checklist
Complete maintenance schedule (5 service intervals)
Repair forecasts with mileage and cost context
Full buyer-fit guidance and who should avoid it
Full specs and trim-level context
Full safety recall details
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FAQ

FAQ

Is the 2021 Mercedes-Benz S-Class reliable?

The CarFocal Reliability Score for the 2021 Mercedes-Benz S-Class is 9.0/10. Reliability score is 9.0/10. NHTSA recalls: 0. Owner complaints: 0.

How practical is the 2021 Mercedes-Benz S-Class for daily use?

Practicality score is 7.8/10. The score is supported by solid day-to-day usability signals. Seating capacity is 5. 4 passenger doors are listed. Boot capacity is 528 litres.

What is the overall score for the 2021 Mercedes-Benz S-Class?

The CarFocal Overall Score for the 2021 Mercedes-Benz S-Class is 6.9/10. Overall score is 6.9/10 (Good). Confidence 41%. Maintenance 8.9/10. Practicality 7.8/10.

What does it cost to own and maintain a 2021 Mercedes-Benz S-Class?

Based on Carfocal's data, First listed service: - Synthetic Oil Change (5W-40) (Parts: 5W-40 Synthetic Oil, Oil Filter) - Tire Rotation and Pressure Check - Brake System Inspection - Fluid Level Checks (Coolant, Brake, Washer) at 10,000 miles. Estimated first-year maintenance: $500 - $800. Repair prediction highlight: Brake Pads and Rotors (typical at 50,000 miles, estimated cost Min: $800 • Max: $1,500).

What is the MSRP range for the 2021 Mercedes-Benz S-Class?

MSRP range is $109,800 - $132,450.

What engine is in the 2021 Mercedes-Benz S-Class?

Engine specs list Inline-6 / V8. Output is 429-496 hp • 384-516 lb-ft.

What transmission does the 2021 Mercedes-Benz S-Class use?

According to CarFocal's specs for the 2021 Mercedes-Benz S-Class, transmission is Automatic. The paired drivetrain is AWD.

What driver assistance and safety features are available on the 2021 Mercedes-Benz S-Class?

11 standard and 2 optional driver assistance features. Key features include Anti-lock Braking System, Electronic Stability Control, Traction Control.

What is the fuel economy range for the 2021 Mercedes-Benz S-Class?

According to CarFocal's specs for the 2021 Mercedes-Benz S-Class, fuel economy range is 20-24 mpg combined.

How many people fit in a 2021 Mercedes-Benz S-Class?

According to CarFocal's specs for the 2021 Mercedes-Benz S-Class, seating capacity is 5.

What body style is the 2021 Mercedes-Benz S-Class?

According to CarFocal's specs for the 2021 Mercedes-Benz S-Class, body style is chassis_cab.

What drivetrain does the 2021 Mercedes-Benz S-Class use?

According to CarFocal's specs for the 2021 Mercedes-Benz S-Class, drivetrain is AWD. Transmission is Automatic.